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Why is the reverse reaction of endoprotease catalyzed hydrolysis of POMC (the endoprotease catalyzed condensation of ACTH with the remaining polypeptide fragment of POMC) generally not observed under physiological conditions?Choice A, The endoprotease responsible for the hydrolysis reaction does not lower the activation energy for the reverse condensation reaction.(Choice B, The endoprotease in question lowers the activation energy for the condensation reaction, but not enough for it to occur under physiological conditions.(Choice C,The endoprotease responsible for the reaction undergoes a permanent alteration to its active site during the hydrolysis reaction.(Choice D, The endoprotease responsible for the hydrolysis reaction lowers the Gibbs free energy of ACTH but not POMC.

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