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Which of the following statements represents the best explanation for why db/db mice produce abnormally high levels of leptin?Choice A, The db gene codes for a transcription factor bound by leptin in the nucleus of adipocytes, and this transcription factor is constitutively active in db/db mice, resulting in leptin resistance in leptin-sensitive cells and hypersecretion of leptin by leptin-producing cells.(Choice B)BThe db gene codes for a transmembrane receptor on the surface of leptin sensitive cells, and this transmembrane receptor is constitutively active in db/db mice, resulting in leptin resistance in leptin-sensitive cells and hypersecretion of leptin by leptin-producing cells.(Choice C)CThe db gene codes for a transmembrane receptor on the surface of leptin sensitive cells, and this transmembrane receptor is rendered inactive in db/db mice, resulting in leptin resistance in leptin-sensitive cells and hypersecretion of leptin by leptin-producing cells.(Choice D)DThe db gene codes for a transcription factor bound by leptin in the nucleus of adipocytes, and this transcription factor is inactivated in db/db mice, resulting in leptin resistance in leptin-sensitive cells and hypersecretion of leptin by leptin-producing cells.

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