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Toutes ces glandes sont entourées d'une capsule conjonctive dont se détachent des cloisons qui s'enfoncent dans le parenchyme et délimitent des lobules. Vaisseaux et nerfs empruntent ces cloisons depuis le hile pour se disperser dans la glande. Le tissu glandulaire à proprement parler est de type acineux (séreux, muqueux ou mixte) entouré de cellules myoépithéliales. La salive élaborée par les acini est recueillie par de petits tubes collecteurs appelés canaux intercalaires formés d'un épithélium monostratifié aplati; ils confluent pour former des canaux intralobulaires souvent striés qui deviennent des canaux interlobulaires dans les cloisons conjonctives.

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