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The Threefold Mosaic Covenant- We remember last time with the golden caf, the Levites stayed with Moses and killed all those Who had sinnedDid all the Levites band together again?

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抗生素濃度相關:Aminoglycoside耳毒、Fluoroquinolone、Metronidazole時間相關:β-lactam、Glycopeptide(萬古黴素)、Clindamycin抗生素配對原則:殺菌配殺菌(心內膜炎),抑菌配抑菌。腎毒:萬古黴素、Cosplatin、Amophtericin、Methoxyflurane、Cyclosporine A、Aminoglycoside1.)抑制細胞壁、膜一殺菌(Ex.Penicillin,Cephalosporins、Monobactams、Carbapenems、Vancomyin、Bacitracin)2.)影響蛋白質一抑菌(Ex.四環黴素(-cycline)、Macrolide巨環類 (-thromycin)、Chloramphenicol氯黴素、Lincosamide林克醯胺) 殺菌(Ex.Aminoglycosides)3.)影響核酸一抑菌(Ex.Sulfonamide) 殺菌(Ex.Metronidazole、Quinolone、Rifampin)所以Chloramphenicol(抑菌)+Piperacillin(菌)一拮抗作用。蛋白質合成抑制(30S): 四環黴素(-cycline)、AMG(可逆/mRNA錯誤解讀)蛋白質合成抑制(50S): Macrolide巨環類 (可逆)(-thromycin)、氯黴素、Lincosamide林克醯胺(可逆)、Streptogramin鏈"陽"黴素Linezolid: 結合"50S"的"23S"、抑制"70S"起始複合物協同β-lactam+AMG: 更易進入Amphoterin B+Flucytocine: 更易進入鏈黴素+Penicillin: 心內膜炎
The prevalence of the H1N1 virus has caused employers to update their health and safety standards.
影響核酸(殺菌、除Sulfonamide抑菌)1.Quinolone (-floxacin): (殺菌)干擾DNA gyrase (Topoisomerase II & IV)、廣效、尿道感染/腦膜炎、濃度有關、須空腹(制酸劑/牛奶no)、CNS/脂肪穿透差、腎排副作用: 破壞軟骨生長(小孩/孕婦NO)、肝指數、腎毒(C6-F)抗癌藥Anthracycline、Etoposide: 抑制Topoisomerase II抗癌藥Irinotecan、Topotecan: 抑制Topoisomerase I一代: Nalidixic acid (G6PD no)、Pipemide acid: 尿路感染二代: Ciprofloxacin(Ciproxin): BBB(炭疽桿菌)、綠膿桿菌、抗藥性TB、抑制CYP1Á2(影響茶鹼代謝)NorfloxacinOfloxacin: 砂眼披衣菌Enoxacin: 抑制CYP1Á2(影響茶鹼代謝)三代:Lomefloxacin: 半衰期長、光敏Levofloxacin(Cravit): 左旋、性病(除了前列腺炎/梅毒)、S.肺炎鏈球菌/呼吸道感染Sparfloxacin: 呼吸道感染、副作用(QT延長、心律不整、抑制CYP1Á2)Grepafloxacin四代:Moxifloxacin(Avelox): 肝臟代謝、尿道感染no、副作用(QT延長、心律不整)GemifloxacinTrovafloxacin: 肝毒性、不能用超過14天2.Sulfonamide: (抑菌)類似PABA、競爭Dihydropteroate合成(干擾葉酸生成)、廣效/尿道感染副作用: 新生兒黃疸、腎毒、G6PD、結晶尿、小腸吸收好(除Sulfasalazine/結腸炎/克隆氏症)禁止: 孕婦、新生兒、+Methenamine治療UTI(會結合甲醛)全身性:(短效)Sulfapyridine、Sulfamerazine、Sulfamethazine、Sulfathiazole、Sulfapyrimidine(中長效)Sulfamethoxazole: 也治療愛滋病併發症(治療UTI)Sulfathiazole、Sulfamethizole、Sulfisomidine非全身性:(腸道感染用): Sulfasalazine、Olsalazine、Succinyl Sulfathiazole(外用)Sulfacetanide(結膜炎)、Silver Sulfadiazine(燙傷)、(燙傷/厭氧菌)

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