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- The infectious particle-elementarybody(EB) is DNA rich,300nmin diameter- EB binds with the host cell and enters by endocytosis- Shortly after entry,the disulfide bonds of the EBmembrane proteins are no longer cross-linked, and after about 8h the EB differentiates into the larger (800-1000nm), non-infectious, metabolically active reticulate body (RB), which divides by binary fission.- By 20h post infection, a portion of RB have begun to reorganise into a new generation of EB.- These reach maturity after 30 hand rapidly accumulate within the endocytic vacuole, which may contain >1000 organisms.They are released by lysis of the host cell 48h after the start of the cycleC.trachomatis- Trachoma:o chronic keratoconjunctivitis that begins with acute inflammatory changes in the conjunctiva and cornea and progress to scarring and blindness.- genital infections and conjunctivitiso Men: non-gonococcal urethritis.o Women: urethritis, cervicitis, pelvic inflammatory disease (can lead to sterility and predispose to ectopic pregnancy).- The newborn acquires the infection during passage through an infected birth canal.- lymphogranuloma venerumo Primary stage - At the site of inoculation (small, painless papule)o Secondary stage - In the regional limph nodes and/or rectum (painful inguinal and/or femoral limphadenopathy = bubo)o Tertiary stage (after a latent period of several years, rare) - widespread destruction of external genitalia, limphatic obstruction

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