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抗分枝桿菌(TB/痲瘋)一線: INH、Rifampin、Ethambutol、Pyrazinamide、Streptomycin鏈黴素二線: Aminosalicylic acid、Cycloserine、Ethionamide、FQ、AMG、巨環類痲瘋: Dapsone (DDS)、Rifampin、Clofazimine、Thalidomide1.)INH: 前驅藥(需要菌的KatG活化)、目標為inhA和β-lactam、細菌休息則抑菌/反之殺菌、基因個體影響(乙醯化去活性)副作用: 周邊神經炎(補充Vit.B6/Pyridoxine)、肝炎、抑制CYP450、紅斑性狼瘡LIS2.)Rifampin (RMP): 抑制DNA依賴的RNA polymerase、殺菌、腦膜炎/痲瘋有效、不可以單用)副作用: 促進CYP450、肝毒/腎衰竭3.)Pyrazinamide (PZA): 對分裂中的最有效果、副作用高尿酸:、肝毒性4.)Ethanbuton (EMB): 抑制arabinosyl transferase(有關細胞壁)、和其他並用效果加乘副作用: 腎臟排除(肝毒低)、視神經炎5.)鏈黴素(SM) : 抑制"30S"、耳毒/腎毒/神經毒
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