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Suppose the frequency of corrected WT (HDR) alleles is 0.1, and the frequency of indel alleles is 0.6, and the frequency of uncorrected SCD alleles is 0.3.If the alleles are randomly and independently distributed in the treated HSPCs, what percentage of HSPCs will have at least one copy of the corrected WT (HDR) allele?Hint: calculate the frequency of cells where both copies became WT HDR alleles (homozygotes) and add the frequency of cells where one copy became WT HDR allele but the other copy is either an indel or SCD (heterozygotes). Even though there are 3 alleles, you can simplify it into a 2-allele system: HDR vs non-HDR, where the non-HDR allele frequency is the sum of the indel and SCD allele frequencies. Then you can apply Hardy-Weinberg formulas for homozygotes and heterozygotes. Or you can use simple rules of probability.

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