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rupture conceptuelle : le milieu intérieur-organisme dans son ensemble soumis à un déterminisme physiologique- constance du milieu interieur garantit indépendance de l'organisme face aux variations du milieu ext => homéostasierupture méthodologique : la méthode experimentale-observation, idée/hypothèse, expérimentation, doutedescription de la fonction glycogénique du foiedistingue sécrétion interne et externe
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