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receptors in the immune responseo PPR - how does the innate system's professional phagocytes [macrophage, dendriticand natural killers] target flawed cells for killing - how recognize and kill them?o How do these antigen presenting cells bring backs bits of these dead cells to the body'simmune system's B and T cells? Discuss the role of the MHC2 receptors and thelysosome.o How does a normal healthy cell prove to the immune system that its is OK? Discuss therole of the proteasome/TAP/MHC1 display.o Discuss how a newly "born" naïve B cell rearranges its antibody genes to produce aunique antibody receptor.o How does a newly activate B cell manipulate its antibody genes to make a best fitantibody while it proliferates within the developing germinal center?o How can flawed body cells [tumor cells] display of PD-L1 down regulate attack from Tkiller cells - allowing these cells to continue to live? How do synthetic antibodies foreither PD-1 or PD-L1 [Keytruda] prevent this down regulation - allow the body'simmune system to efficiently attack the cancer cells?

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