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Prostate adenocarcinoma pathophysiology:- Androgen --> Activate --> Pro-growth and pro-survival genes- _____ with the shortest stretches of polyglutamine (CAG) have the highest sensitivity to androgens- _____ mutations increase risk 20-fold- _____ of the glutathione S-transferase gene- Diet: risk associated with increased _____ consumption- Precursor _____: prostatic intraepithelial neoplasia (PIN)- Despite all this evidence, we do not know the natural history of PIN, and in particular how often it progresses to cancer
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