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Opportunistic Mycoses;- Present in our microbiota (Candida)- Ubiquitous fungi (air, soil, water)- Hosts; immunocompromised persons, underlying predisposing conditions of the host- More common diseases; candidiasis,cryptococcosis, aspergillosis, mucoromycosis, pneumocystis pneumonia, penicillinosisPathogenesis:- Host immune system (cellular immune system + risk factors)-> play important role- Tropism to glycogen containing tissue (tropismiontyypillistä glycogen containing tissue):o Adherence to mucosal cells (surface glucomannan receptors on the yeast may bind to fibronectin covering the epithelial cells)o Invasiveness; associated with shift from yeast to the hyphal formo Pseudohyphae - proteolytic & lipolytic activity- Endotoxins (has low activity)- True hyphae-> provide deep invasion- Corticosteroids binding receptors on the surface of C.aRisk factors:Antibacterialtherapy, Corticosteroidtherapy, Local&invasiveinfection, Diabetesmellitus, Aids(immunosuppression), Invasiveprocedures, Macerated,wetskin

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