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-non systématique -Adapté à l'âge et aux comorbidités -principalement proposé en cas d'atteinte ganglionnaire multiple et/ou anémie et/ou thrombopénie -Chimiothérapie orale chez la personne âgée -protocole agressif chez les patients jeunes -Seule l'allogreffe de moëlle permet la guérison (mais l'utilisation est restreinte)
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