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Name: Liothyronine or Triiodothyronine (Cytomel)MOA: T3 binds to specific receptor proteins (alpha & beta) in the nucleus, resulting in altered gene expression, and increased formation of RNA and proteinSystemic effects include increased oxygen consumption by most tissues of the body and increases the basal metabolic rate and the metabolism of carbohydrates, lipids and proteinsIndications: Replacement therapy or supplement in patients with hypothyroidismShort term suppression of the pituitary thyroid-stimulating hormone (TSH) in the treatment or prevention of various types of euthyroid goiters, including Hashimoto's As diagnostic agents in suppression tests to differentiated suspected mild hyperthyroidism or thyroid gland autonomyADME: taken orally or parenterallyshort half life (24hrs) compared to T4 (7 days), requiring multiple daily dosesAdverse Effects: Symptoms resembling hyperthyroidism: nervousness, anxiety, tremor, heat intolerance, weight loss with increased appetite, palpitation, cardiotoxicityContraindications: heart disease (T3 can cause cardiotoxicity)Notes: costs more than T4 (Money on bag)has a shorter t1/2 (requiring multiple daily doses) compared to T4is more difficult to monitor using conventional lab tests
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