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Mutations due to small insertions and deletions can arise spontaneously during DNA replication due toa tautomeric shift taking place so that cytosine in the new DNA strand is able to pair with an adenine in the template strand.a purine in the template DNA strand mispairing with an incoming pyrimidine.a purine in the template DNA strand mispairing with an incoming purine.depurination of guanine.strand slippage.

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