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Lorsque les gènes impliqués dans le contrôle du cycle cellulaire est muté cela peut provoquer un cancer : par exemple le gène p53 codant pour la protéine P53 dont le rôle est de déclencher de gènes impliqués dans le blocage du cycle cellulaire et dans la réparation de l'adn dans une cellules quand ce derniers comporte une lésions. Cette protéine peut également permettre la transcription de gènes entraînant la mort de la cellule en cas d'ADN trop endommagé.

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