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L'ADN n'est pas une molécule totalement stable : il se produit des erreurs. Elles peuvent être
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- C. 46,XY,-21,rob(14;21)(q10;q10)All of the listed karyotypes are possible when this woman mates with a karyotypically normal male. However, 46, XY,-21, rob(14;21)(q10;q10) is trisomy 14, which is not viable and therefore would not be seen in the liveborn offspring of this couple. Of viable offspring in such a mating, 50% have a balanced translocation [ 45, XY,-14,- 21, rob(14;21)(q10;q10) or 45,XX,-14,-21,rob(14;21)(q10;q10)], 40% are karyotypically normal [46, XX] , and 10% have an unbalanced translocation and Down syndrome [46, XY,- 14, rob(14;21)(q10;q10)].