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​Kinesin requires ATP hydrolysis in order to propel its movement along the microtubule. If the ATP binding site was misfolded, it could cause one of two possibilities to occur: 1. ATP binds but cannot be hydrolyzed. 2. ATP cannot bind at all. In either case, the consequence is the same in that the motor protein will not move and protein cargo within the endomembrane system will not be delivered beyond the Golgi apparatus.

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