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Keep a copy of your _____ where you can see it and read it every day

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NAME: Metformin (Glucophage)MOA: Decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilizationClinical: First-line treatment of T2DM, prevention of T2DM in individuals with pre-diabetesADME: onset is days with maximum effect in about 2 weeks, high Vd due to partitioning into liver, kidney, and GI tract, 90% excreted unchanged in urine, CONTRAINDICATED in renal failure (GFR < 70)AE: Gastrointestinal (most common, titrate to desired dose slowly, take with food, GI discomfort essens over several weeks, XR may reduce GI effects), malabsorption of vitamin B12 and folate, metallic taste, lactic acidosis with renal insufficiency (rare)Contraindications: Absolute contraindications: severe renal impairment (GFR < 30 ml/min/1.73 m2), known metformin hypersensitivity, acute or chronic metabolic acidosis, including diabetic ketoacidosis (treat DKA with insulin)Relative contraindications: 30 < GFR < 45 30 ml/min/1.73 m2, pause metformin for 48 hours following radiology with contrast, alcoholic patients, patients with severe hepatic impairmentInteractions: Alcohol, others. Check for drug interactions

Name: Inhaled corticosteroids. Fluticasone, mometasone, beclomethasone. They end in "-one" (the 1 candle on the cake) MOA: Suppresses airway inflammation Use: Primarily asthma: fewer asthma symptoms, increased lung function, improved asthma-specific QOL, fewer asthmatic exacerbation (happy birthday asthma)Adverse Effects: Sore throat (red throat), coughing on inhalation (the blue lines look like a cough), weak or hoarse voice (toy horse), candidiasis (candies AND the white mouth)

NAME: Sulfonylureas glipizide (Glucotrol) (TROLL) and glyburide (Diabeta) (dead beta fish) MOA: enhance insulin release (the troll's chest has an arrow pointing up with an "I" to signify iodine) Clinical: combination therapy of T2DM (the eyes have a 2) ADME: oral (pink lips) AE: hypoglycemia, weight gain (note the belly), GI, derm rxns (pink rashes), dizziness (swirls), HA (red hairs), anxiety (the swirls around the head) Contraindications: sulfonamide hypersensitivity (exclamation points on yellow hairs), T1DM and DKA (earrings) Interactions: Notes:

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