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In 1668, Francesco Redi performed a series of experiments on spontaneous generation. He began by putting similar pieces of meat into eight identical jars. Four jars were left open to the air, and four were sealed. He then did the same experiment with one variation: Instead of sealing four of the jars completely, he covered them with gauze (the gauze excluded the flies while allowing the meat to be exposed to air). In both experiments, he monitored the jars and recorded whether or not maggots (young flies) appeared in the meat.

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