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Hemoglobin aggregates in sickle cell disease due to a mutation that changes a specific glutamate (Glu) to a valine (Val). What would you expect in the case of a Glu to aspartate (Asp) mutation? Select all that applyA. A change in primary structureB. Aggregation similar to sickle cellC. Large-scale disruption of tertiary structureD. Large-scale disruption of quaternary structureE. Little or no effect on three-dimensional structureF. None of the above

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