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Giả thuyết nguyên nhân khác, đáng tin cậy hơn là giả thuyết dưỡng thần kinh: là do sự thiếu hụt yếu tố hỗ trợ tăng sinh vùng liềm của não, làm teo thần kinh, mất tế bào thần kinh đệm.Chứng cứ: ...Thí nghiệm trên chuột: cho chuột stress kéo dài thì thấy vùng hồi hải mã và vỏ não trán trước teo nhỏ, giảm số nhánh, giảm số gai thần kinh, giảm số synapse với các neuron từ những vùng não khác.⇒ Muốn điều trị trầm cảm, phải dùng thuốc nào đó ngăn chặn sự teo nhỏ các cấu trúc thần kinh nêu trên.

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