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Figure 4b from DeWitt et al. 2016 shows the percentage of alleles created by homologous recombination (HDR) and NHEJ deletion mutations (indel). Suppose the frequency of corrected WT (HDR) alleles is 0.1, and the frequency of indel alleles is 0.6, and the frequency of uncorrected SCD alleles is 0.3.If the alleles are randomly and independently distributed in the treated HSCs, what percentage of HSCs will have at least one copy of the corrected WT (HDR) allele?
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