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DeWitt et al. 2016 results clearly show that CRISPR-Cas9 system produces more deletion mutations than homologous recombination events, even when a homologous wild type DNA segment is provided into the cells along with the Cas9-sgRNA ribonucleoprotein (RNP) complex. These deletions are of just a few nucleotides. What will be the consequence of these small deletions in the beta-hemoglobin (HBB) gene? Select all true statements below.a one-nucleotide deletion will affect the structure and function of the protein less than a 3-nucleotide deletiona one- or two-nucleotide deletion will render the protein completely non-functionala three-nucleotide deletion has a good chance of still making a functional beta-hemoglobin protein

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