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- Defined prescription drugs as requiring a prescription from a physician- Separated OTC from legend drugs- Defined OTC and legend drugs- Labeling is required from prescription*Federal laws prohibit the sale without prescriptiona. The Pure Food and Drug Act 1906b. The Food, Drug, and Cosmetic Art 1938c. The Durham - Humphrey Amendment 1951d. The Kefauver - Harris Amendment 1962e. The Controlled Substances Act 1970f. The Orphan Drug Act 1983
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