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A 75-year-old woman with a history of type 2 diabetes mellitus, for which she is treated with insulin therapy, is admitted to the intensive care unit for severe hypoxemia due to community-acquired pneumonia. The patient is intubated and has a central venous catheter in place. She develops a new fever on day 5 of admission and blood cultures return Candida. Her most recent vital signs include a HR of 105 bpm, BP of 140/80 mm Hg, RR of 12/min, pulse oxygenation of 96% on mechanical ventilation, and T of 100.2°F. On physical examination, the patient is sedated and intubated with crackles in the right lower and middle lung fields. There is no erythema or drainage from the site of the catheter insertion. Her most recent complete blood count results include a white blood cell count of 12,000 cells/µL and neutrophils 8,000/µL. Which of the following is the recommended management of the patient’s most recent blood culture results?ARemove the central line and repeat blood culturesBRemove the central line and start amphotericin BCRemove the central line and start caspofunginDStart amphotericin B without removing the central lineEStart caspofungin without removing the central line

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