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A 33-year-old HIV-positive woman has had increasing inability to think clearly, with forgetfulness, over the past 3 weeks. She now has trouble doing everyday tasks. She has no history of seizures, headaches, nausea, vomiting, fever, chills or diarrhea. On examination she is oriented to time, place and date. She is indifferent to her surroundings. She is unable to perform calculations and has difficulty in word finding. She is afebrile. MR imaging of the brain shows an irregular ring-enhancing lesion in the white matter of the left frontal lobe. Her CD4 count is 90/microliter. Which of the following is the most likely diagnosis?

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