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この「バライオレーション」というのは、1721年のボストンでの大規模な天然痘の流行時に行われた方法です。この時、天然痘が広まっていて、多くの人が感染していました。この状況下で、「バライオレーション」と呼ばれる手法が話題になりました。この手法では、健康な人に天然痘の病気の人から少量の物質を与えることで、免疫を獲得する試みが行われました。このバライオレーションが注目される中で、当時の2人の有名な人物、一人は保守的な宗教指導者であるコットン・マザー、もう一人は18世紀のアメリカ科学と文学の中心人物とされるベンジャミン・フランクリンが関与しました。

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