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Cependant, pour François Perroux (1966, L'économie du XXe siècle) etsa théorie des pôles de croissance, la croissance se manifeste dans des pôles de développement à intensité variable et n'apparaît pas partout à la fois. La concentration d'entreprises crée des pôles dynamiques du fait de la production des externalités positives. La régionalisation serait donc à l'origine de pôles au sein desquels les rendements factoriels sont croissants et où l'investissement y est plus rentable qu'ailleurs. Cela creuserait à l'inverse la divergence des niveaux de vie entre les pays. Le modèle gravitationnel du commerce international dressé par Jan Tinbergen (1962) en tire des conclusions similaires : les pays auraient, selon leur taille et la distance qui les sépare les uns des autres, une tendance au bilatéralisme, et les grandes zones s'attireraient donc.

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