Medicine Questions
Explore questions in the Medicine category that you can ask Spark.E!
What is the most common type of phase II metabolism reaction?
How does polarity affect volume of distribution?How does lipophilicity affect volume of distribution?
Morphine and hydrocodone are parent drugs but also ? of codeine.
The ? enzyme is one of the most involved CYPs.
What type of CYP has the highest percentage of drugs metabolized by it?
? and ? are not commonly main elimination routes?
When was CYP450 catalysis discovered?
The parent compound can be a ? of another parent drug.
What type of CYP has the highest relative hepatic content?
Some drugs do not reach systemic ciruclation and get eliminated...
What types of compounds are excreted through the lungs?
Is the Vd higher for hydrophilic or lipophilic drugs?
What does glomerular filtration depend on?- Rate?- What type of drugs are often eliminated through the bladder (in urine) in this step?
Drugs are mostly metabolized by what enzyme systemes?
What are common examples of hydrolysis reactions in drug metabolism?
In some cases, ? can happen at both sites in phase II metabolism?
What is important about heme for oxidation and reduction reactions?
What type of phase I enzymes need a cofactor?
What happens when lipophilic drugs are reabsorbed into the renal vein?
What type of chemical reaction do CYP enzymes carry out in phase I metabolism?