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Jetlag is caused by travelling through multiple time zones in a short period of time. Travelling eastwards is a particular problem. The circadian rhythm (set at the origin of travel) no longer matches the day-night times in the new location. This can result in the person feeling sleepy in the day or being awake during the night. It takes a few days for the circadian rhythm to adjust to local conditions, by light signals transmitted to the hypothalamus modifying melatonin secretion. Some travellers take melatonin to match the night time in their destination. Melatonin can help reduce jetlag.
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