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Increase in FSH secretion causes follicle development in the ovary. A follicle contains an oocyte (egg) surrounded by a layer of follicle cells. The follicle cells secrete estrogen. Estrogen causes the endometrium to thicken and become highly vascularized. Estrogen inhibits the secretion of FSH (negative feedback). Estrogen promotes the secretion of LH. LH stimulates the follicle cells to secrete more estrogen. More estrogen promotes a surge in LH (positive feedback). Surge in LH causes ovulation.

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