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test d'invasion 3D sur une matrice de collagene-permet de quantifier la capacité d'--- de cellules tumorales en 3D-parametres importantes de l'invasion: --- des cellules à la matrice, l'activité des ---, et la capacité des cellules à se --- dans les interstices.-methode: tumeur spheoride est depose sur le --- = matrice riche en proteines de la matrice extracellulaire, composé essentiellement de --- iv et ---. l'invasion du matrice est suivie par microscopie à --- --- --- et la capacité d'invasion correspond à la surface/diametre de la zone invahie.

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