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MAI 2017 QCM 45- Certains patients affectés de maladies impliquant une activation anormale du complément sont traités par un anticorps thérapeutique dirigé contre la protéine C5. Cet anticorps empêche le clivage du C5 par les C5 convertases. A- La protéine C5 s'associe à la protéine C2 pour former la C3 convertase de la voie classique B- Si l'on effectue une mesure de l'activité fonctionnelle de la voie classique (CH50) chez un patient traité par anti-C5, elle sera diminuée.C- L'activité fonctionnelle de la voie alterne de ce patient sera normale D- Ce patient aura un risque majoré d'infections bactériennes, en particulier méningococcique E- L'anticorps thérapeutique anti-C5 est une IgG1, afin d'éviter qu'il n'induise une activation de la voie classique une fois fixé sur sa cible

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