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la présence de plusieurs dimères sous forme GTP à l'extrémité du microtubule stabilise la structure en ralentissant l'hydrolyse en GDP. On parle à ce moment-là d'une coiffe GTP qui protège l'extrémité et qui permet la croissance rapide. A l'inverse, une extrémité riche en GDP-tubuline se dépolymérise 100 fois plus vite qu'une extrémité avec du GTP-tubuline si bien que si des dimères GDP sont exposés à l'extrémité il va y avoir une dépolymérisation rapide et catastrophique.

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