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Hormone du pancréas anabolisante se fixe R à activité Tk 1 liaison au R = chgmt de conformation 2 Autophosphorylat° des chaîne bêta 3 phosorylation Pr et substrats 4 Cascades biochimiques 5 effet pleiotropes : transport du Glc' synthèse de glycogene, lipogenese,synthèse protéique, expression des gènes, synthèse ADN, inhibions apopoptoseDiabète substitution car défaut de synthèse
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