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2022 QCM 5 :Vous prescrivez un bilan du complément chez un jeune garçon de 10 ans ayant présenté plusieurs épisodes d'infections bactériennes pyogènes sévères, dont une infection à N. Meningitidis l'ayant conduit en réanimation médicale. CH50 (activité fonctionnelle de la voie classique) : normale AP50 (activité fonctionnelle de la voie alterne) : indétectable Taux sérique des protéines C3 et C4 du complément normal A. La voie terminale commune du complément fonctionne normalement chez ce jeune garçon. B. En l'absence de dosage du facteur H ces résultats ne sont pas interprétables. C. La normalité du taux de C3 exclut toute anomalie de la voie alterne. D. Un dosage de la properdine est nécessaire pour compléter ce bilan. E. Ces résultats évoquent un déficit en C6

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