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Immunology

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polymorphisms cause MHC to be seen as _______ upon transplant
Generation of BcR & TcR diversityImprecise and random events occur when DNA ______ and is __________ allowing nucleotides to be lost or new ones to be inserted
each MHC molecule presents a ________ range of peptides
T cell selection in the thymus''the process of T-cell selection in the thymus eliminates the ____ and rejects the __________''
A single MHC molecule presents peptides with a shared sequence or __________
recognition of antigenThe T cell receptor (TcR) has to have antigen _____________ to it on Major Histocompatibility Complex (MHC) molecules on another cell
____________ cells only bind antigen on class II MHC
Generation of BcR & TcR diversitymultiple contiguous copies of ________________ gene segments are present in BcR/TcR gene loci. these are ____________________ selected during somatic recombination
Clonal SelectionWhen the T/B cell binds its specific antigen, it ________ and __________
Generation of BcR & TcR diversitycomplete function genes that encode a variable region are generated by_________________ of separate ______ segments
The BcR is a ____________ version of an antibody with identical specificity
B cell receptors (BcR) and T cell receptors (TcR) contain _______ regions and _________ regions
Clonal Selectiondaughter cells express ________ receptor to the parent
Generation of BcR & TcR diversityvariable regions are encoded by ____________,_____________+______________ gene segments
Clonal Selection____________ population mediates immune response
once specific cells have been activated, they are called ______ T/B cells and some become _________ T/B cells
Clonal Selectionsome daughter cells become ________ cells. these are maintained at a _______ frequency and are primed to respond _____ in future
Clonal Selectioneach naive T or B cell bears receptors of
antibodies are ______ shaped soluble secreted molecules which circulate in the ____________
self/non-self signals recognised by the ___________ system

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