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The role of the CD3 proteins and ζ chain on the surface of the cell is totransduce signals to the interior of the T cellbind to antigen associated with MHC moleculesbind to MHC moleculesbind to CD4 or CD8 moleculesfacilitate antigen processing of antigens that bind to the surface of T cells.

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Which of the following describes the sequence of events involved in the processing of peptides that will be presented as antigen with MHC class II?protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II →endocytosis →plasma membraneendocytosis →protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II →plasma membraneremoval of CLIP from MHC class II →binding of peptide to MHC class II →protease activity →endocytosis →plasma membranebinding of peptide to MHC class II →endocytosis →removal of CLIP from MHC class II →protease activity →plasma membraneplasma membrane →endocytosis →protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II.

Which of the following statements is TRUE regarding TCR structure and function?There are three types of TCRs and they are given the following namesTCR rearrangement is completed in the bone marrow before the developing T cells reach the thymusTCRs undergo somatic hypermutation in the thymus but do not undergo isotype switchingTCR gene segments are recombined by RAG proteins and the RAG proteins are similar to transposases found in virusesTCRs are associated with the Ig and Ig co-receptors which help with the signal transduction process

T-cell receptors interact not only with peptide anchored in the peptide-binding groove of MHC molecules, but also withanchor residuespeptide-binding motifvariable amino acid residues on α helices of the MHC moleculeβ2-microglobulininvariant chain.

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