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23) In Figure 17.1, the arrow at time (c) indicatesA) the time of exposure to the same antigen as at time (a).B) the secondary response.C) the primary response.D) exposure to a new antigen.E) the T-cell response.

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Peptides that bind to a particular MHC isoform usually have either the same or chemically similar amino acids at two to three key positions that hold the peptide tightly in the peptide-binding groove of the MHC molecule. These amino acids are called _____ and the combination of these key residues is known as its _____.alleles; allotypesanchor residues; peptide-binding motifallotype; haplotypesinvariant chains; haplotypesrestriction residues; MHC allotype.

Which of the following describes the sequence of events involved in the processing of peptides that will be presented as antigen with MHC class II?protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II →endocytosis →plasma membraneendocytosis →protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II →plasma membraneremoval of CLIP from MHC class II →binding of peptide to MHC class II →protease activity →endocytosis →plasma membranebinding of peptide to MHC class II →endocytosis →removal of CLIP from MHC class II →protease activity →plasma membraneplasma membrane →endocytosis →protease activity →removal of CLIP from MHC class II →binding of peptide to MHC class II.

Which of the following statements is TRUE regarding TCR structure and function?There are three types of TCRs and they are given the following namesTCR rearrangement is completed in the bone marrow before the developing T cells reach the thymusTCRs undergo somatic hypermutation in the thymus but do not undergo isotype switchingTCR gene segments are recombined by RAG proteins and the RAG proteins are similar to transposases found in virusesTCRs are associated with the Ig and Ig co-receptors which help with the signal transduction process

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